- International Publications:
- El-Mezayen NS, Abelrazik YR, Khalifa DM, Dorbouk NM, Moaaz MA, Ali MM, Evy AG, Mohamed EG, Abdelhadi AM, Adly I, Shams NA. Cross-relationship between COVID-19 infection and anti-obesity products efficacy and incidence of side effects: A cross-sectional study. Plos one. 2024 Aug 22;19(8):e0309323.
- Amira AM. Mansour, Mahmoud M Khattab, Aiman S. El-Khatib, Ashraf K. Awaad, Wessam M. El-Refaie, Nesrine S. El-Mezayen. Valsartan as a prophylactic treatment against breast cancer development and niche activation: What molecular sequels follow chronic AT-1R blockade?. Life Sciences. 2024 Jul 31:122939.
- Hend M Dawood, Neveen M. Barghouth, , Reham S. Ibrahim, Eman Shawky. Metabolomic insights into the therapeutic mechanisms of costus (Saussurea costus (Falc.) Lipsch.) root extract in propylthiouracil-induced hypothyroidism rat model. Journal of Ethnopharmacology. 2024 Apr 24;324:117784.
- Ashraf A. Noah, Nesrine S. El-Mezayen, Samar O. El-Ganainy, Inas E Darwish, Elham A. Afify. Reversal of fibrosis and portal hypertension by Empagliflozin treatment of CCl4-induced liver fibrosis: Emphasis on gal-1/NRP-1/TGF-β and gal-1/NRP-1/VEGFR2 pathways. European Journal of Pharmacology. 2023 Nov 15;959:176066.
- Asser F. Bedair, Ahmed Wahid, Nesrine S. El-Mezayen, Amira F. El-Yazbi, Hadeel A. Khalil, Elham A. Afify. Nicorandil/morphine crosstalk accounts for antinociception and hepatoprotection in hepatic fibrosis in rats: Distinct roles of opioid/cGMP and NO/KATP pathways. Biomedicine & Pharmacotherapy. 2023 Sep 1;165:115068.
- Mona A. Moustafa, Wessam M. El-Refaie, Yousra S. Elnaggar, Nesrine S. El-Mezayen, Ashraf K. Awaad, Osama Y. Abdallah. Fucoidan/hyaluronic acid cross-linked zein nanoparticles loaded with fisetin as a novel targeted nanotherapy for oral cancer. International Journal of Biological Macromolecules. 2023 Jun 30;241:124528.
- Nesrine S. El-Mezayen, Mennat-Allah Magdy Attia, Mohanad Yehia Shafik, Hadeer Galal Gowied, Hadeer Ahmed Abdel-Aal, Sara Medhat Abdel-Hady, Mostafa Said Ghazy. Reactive Astrocytes Targeting with Oral Vitamin A: Efficient Neuronal Regeneration for Parkinson’s Disease Treatment and Reversal of Associated Liver Fibrosis. CNS Neuroscience & Therapeutics. 2023; DOI: 10.1111/cns.14179
- Asser F. Bedair, Ahmed Wahid, Nesrine S. El-Mezayen, Elham A. Afify. Nicorandil reduces morphine withdrawal symptoms, potentiates morphine antinociception, and ameliorates liver fibrosis in rats. Life Sciences. 2023:121522.
- Sarah M. Shoukry, Amr El-Hawiet, Nesrine S. El–Mezayen, Nabila M. Ghazy, Reham S. Ibrahim. Unraveling putative antiulcer phytoconstituents against Helicobacter pylori urease and human H+/K+-ATPase from Jacaranda mimosifolia using UPLC-MS/MS coupled to chemometrics and molecular docking. Microchemical Journal. 2023:108550.
- 10. Aya A. Mabrouk, Nesrine S. El-Mezayen, Ashraf K. Awaad, Mina I. Tadros, Omaima N. El-Gazayerly, Wessam M. El-Refaie.
- Novel celecoxib-loaded chitosan-fucoidan nanoparticles as potential immunotherapy for oral squamous cell carcinoma: Mechanistic insights. Journal of Drug Delivery Science and Technology. 2023; 81:104228.
- Aya A. Mabrouk, Nesrine S. El-Mezayen, Mina I. Tadros, Omaima N. El-Gazayerly, Wessam M. El-Refaie. Novel Mucoadhesive Celecoxib-loaded Cubosomal Sponges: Anticancer Potential and Regulation of Myeloid-Derived Suppressor Cells in Oral Squamous Cell Carcinoma. European Journal of Pharmaceutics and Biopharmaceutics. 2023; 182, 62-80.
- Reham S. Ibrahim, Nesrine S. El-Mezayen, Alaa A. El‐Banna. Alleviation of Liver Cirrhosis and Associated Portal-Hypertension by Astragalus Species in Relation to their UPLC-MS/MS Metabolic Profiles: A Mechanistic Study. Scientific Reports. 2022; 12)1(:1-27.
- Nesrine S. El-Mezayen, Rehab A. Abd el Moneim, Safaa H. El-Rewini. Vitamin B12 as a Cholinergic System Modulator and Blood Brain Barrier Integrity Restorer in Alzheimer’s Disease. European Journal of Pharmaceutical Sciences. 2022; 174: 106201.
- Reham S. Ibrahim, Nesrine S. El-Mezayen, Asmaa Khairy, Hala H. Zaatout a, Hala M. Hammoda, Aly M. Metwally. Biologically-Guided Isolation of Natural Lead Antithyroid Drug from Medicago sativa L. Sprouts and Its Toxic Profile in Comparison with Propylthiouracil. Journal of Food and Drug Analysis 2020; 28)3
- Nesrine S. El-mezayen, Wessam F. El-Hadidy, Wessam M. El-Refaie, Th. I., Mahmoud M. Khattab, Aiman S. El-Khatib. Oral vitamin-A-coupled valsartan nanomedicine: High hepatic stellate cell receptors accessibility and prolonged enterohepatic residence. Journal of Controlled Release 2018; volume 283, issue 2018, 32-44.
- Nesrine S. El-mezayen, Wessam F. El-Hadidy, Wessam M. El-Refaie, Th. I. Shalaby, Mahmoud M. Khattab, Aiman S. El-Khatib. Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis. Journal of Controlled Release 2017; 266)2017(226-237.
- Remonda E. Rizk, Wessam F. El-Hadidy, Malak A. Zoheir, Nesrine S. El-Mezayen. Evaluation of the anticarcinogenic effect of some peroxisome proliferator-activated receptor ligands on dimethyl-benz(α) anthracene-induced mammary tumor in female rats. World Journal of Pharmaceutical Research, 2015; Volume 4, Issue 11, 2078-2099.
- Research Projects
- PI to the project applied to: Unit of Research Project, Pharos University in Alexandria, Alexandria Egypt. Project Code Number: PUP-24-6
- Co-PI to the project applied to: Unit of Research Project, Pharos University in Alexandria, Alexandria Egypt. Project Code Number: PUP-24-7
- Patencies:
- Title; Nicorandil reduces morphine withdrawal symptoms, potentiates morphine antinociception, and ameliorates liver fibrosis in rats.
Authors: Asser F. Bedair, Ahmed Wahid, Nesrine S. El-Mezayen, Elham A. Afify
Patency number: EG/P/2022/1921
Date: 28/12/2022
Registered at: Scientific Research Academy
- Title; Empagliflozin in the Treatment of Liver Fibrosis
Authors: Ashraf AlamEldin, Nesrine S. El-Mezayen, Samar O. El-ganainy, Inas Darwish, Elham Awad Afify
Patency number: EG/P/2022/195
Date: 16/2/2022
Registered at: Scientific Research Academy
Supervision of Researchers in Early Career Phases
- Theses supervision:
- PhD Thesis: Phytochemical and biological investigation of costus (Saussurea costus) family Asteraceae
Candidate; Neveen Mohammed Hussein Barghouth
Supervisors: Nesrine S. El-Mezayen, Hend Dawood, Reham S. Ibrahim, Eman Shawky Anwar Mohammad.
Registration: Registered at Faculty of Pharmacy, Alexandria University, 21st of April 2022
- PhD Thesis: Breast Cancer Tumor Micro-Environment Targeting Using Nanocarriers loaded with Neuropilin-1 Epigenetic Modifier and/or Vascular Endothelial Growth Factor Receptor Modulator
Candidate; Shrouk Sherif Kotb El Zokm
Supervisors: Nesrine S. El-Mezayen, Wessam M. El-Refaie, Mahmoud M. Khattab, Melanie Flint.
Registration: Registered at Faculty of Pharmacy, Cairo University, 23rd of May 2021
- PhD Thesis: Pharmacological Targeting of Cancer Stem Cells Activation and Stemness in Chemically-Induced Breast Cancer in Rats.
- Candidate; Amira Magdy MansourSupervisors: Nesrine S. El-Mezayen, Wessam M. El-Refaie, Mahmoud M. Khattab, Aiman S. El-Khatib.
Registration: Registered at Faculty of Pharmacy, Cairo University, 17th of September 2020.
- Master Thesis: An Investigation of the Neuromodulatory Effect of Valsartan in Experimentally Induced Parkinson’s Disease in Rats
Candidate; Hadeer Galal Gowied
Supervisors: Elham Awad Afify, Nesrine S. El-Mezayen
Registration: Registered at Faculty of Pharmacy, Alexandria University, September 2023
- Master Thesis: Crosstalk between Renin-Angiotensin System and Neuropilin Pathways in Adjuvant-Induced Rheumatoid Arthritis in Rats
Candidate; Nourhan Essmat Shahin
Supervisors: Nesrine S. El-Mezayen, Mahmoud M. Khattab
Registration: Registered at Faculty of Pharmacy, Cairo University, 22nd of March 2022.
- Master Thesis: Effects of Empagliflozin on Neuropilin-1 Signaling Pathway in a Rat Model of Experimentally Induced Liver Fibrosis.
- Candidate; Ashraf AlamEldinSupervisors: Nesrine S. El-Mezayen, Inas Darwish, Elham Awad Afify
Registration: Registered at Faculty of Pharmacy, Pharos University in Alexandria, September 2020
Thesis Discussion: 25th of December 2022
- Supervision of senior graduation projects:
- Potential Efficacy and Proposed Mechanisms of Action of Empagliflozin for the Management of Experimentally-Induced Migraine Headache”. This project participated with a poster in the (PUA 2024 “Perspectives in Pharmaceutical Sciences”)
- Anti-obesity Products and COVID-19: A Cross-Sectional Study: This project participated with a poster in the (PHS 2022 “2ND International Conference and Exhibition on Pharmaceutical & Healthcare Sciences”)
- Reprogramming Brain Fibroblasts to Dopaminergic Neurons in Parkinson’s Disease (2020-2021): This project was published internationally (Reactive Astrocytes Targeting with Oral Vitamin A: Efficient Neuronal Regeneration for Parkinson’s Disease Treatment and Reversal of Associated Liver Fibrosis. CNS Neuroscience & Therapeutics. 2023; DOI: 10.1111/cns.14179 (ISI Impact factor 7.035)
- ATP-dependent K Channels Cytoselectivity in Pharmacotherapeutics (2019-2020)
- Antithyroid Potential and Toxic Profile of Propylthiouracil versus Apigenin for managing Induced Hyperthyroidism in Female Rats (2018-2019): This project was published internationally (Reham S. Ibrahim, Nesrine S. El-Mezayen, Asmaa Khairy, Hala H. Zaatout a, Hala M. Hammoda, Aly M. Metwally. Biologically-Guided Isolation of Natural Lead Antithyroid Drug from Medicago sativa L. Sprouts and Its Toxic Profile in Comparison with Propylthiouracil. Journal of Food and Drug Analysis 2020; 28)3( (ISI Impact factor 6.079))
- The Potential Role of Vitamin B12 in Alzheimer’s Disease (2017-2018)
Conferences
- Organizer, Attendee, and participant in the 4th PUA International Conference on “Perspectives in Pharmaceutical Sciences ” (April 2024): Participant with two posters entitled:
– “Potential Efficacy and Proposed Mechanisms of Action of Empagliflozin for the Management of Experimentally-Induced Migraine Headache”
– “Crosstalk between Renin-Angiotensin System and Neuropilin Pathways in Adjuvant-Induced Rheumatoid Arthritis in Rats”
- Attendee and participant in the PHS 2022 “2ND International Conference and Exhibition on Pharmaceutical & Healthcare Sciences” (November 2022): Participant with 3 posters entitled:
– “Anti-obesity Products and COVID-19: A Cross-Sectional Study”
– “Unraveling putative antiulcer phytoconstituents against Helicobacter pylori urease and human H+/K+-ATPase from Jacaranda mimosifolia using UPLC-MS/MS coupled to chemometrics and molecular docking.”
– “Nicorandil reduces morphine withdrawal symptoms, potentiates morphine antinociception, and ameliorates liver fibrosis in rats.”
- Organizer, Attendee, and participant in the 3rd PUA International Conference on “Innovations in Pharmaceutical Sciences” (May 2022): Participant with two posters entitled:
– “Effect of Empagliflozin on Neuropilin-1 Signaling Pathway in Experimental Liver Fibrosis”
– “Modulation of TGF-β/p-Smad/p21 cascade by memantine and rosuvastatin mitigates the cognitive insults and neuroinflammation in Alzheimer’s model in rats”
- Attendee in the “Use of latest Digital Technology in Medical, Pharmaceutical, Biological and Bio-Medical Sciences for Teaching and Research” webinar organized by ADINSTRUMENTS company (December 2021)
- Attendee at the Eleventh Annual National Research Ethics Conference, Uganda National Council for Science and Technology (September 2021)
- Attendee at The 3rd Annual Conference of Neurology Department, Ain Shams Medical Congress (November 2020)
- Speaker at the 2nd PUA International Conference on “Multidisciplinary Approaches in Pharmaceutical Sciences” (March 2020)
- The article: Oral vitamin-A-coupled valsartan nanomedicine: High hepatic stellate cell receptors accessibility and prolonged enterohepatic residence was the title of a speech at the 5th Annual Conference of Egyptian Gastro Hepatic Association, Faculty of Medicine, Cairo University (October 2018)
- Attendee at Biodermatology conference, Faculty of Medicine, Alexandria University (May 2018)
- Attendee at Liver regeneration conference, Faculty of Medicine, Alexandria University (May 2017)
- Attendee at the 1st PUA International Conference on Advances in Pharmaceutical Sciences, 27-29 October 2015 Pharos University in Alexandria.
- 12.Attendee in the 17th conference 5th international (November 2012): Advances in medical research concerning OBESITY, Medical Research Institute- Alexandria University.
- Workshops
- Attending the workshop entitled; “Classroom Management for Special Needs”, 2024, Pharos University in Alexandria.
- Attending the workshop entitled; “Classroom Management for Special Needs”, 2024, Pharos University in Alexandria.
- Speaker on the scientific day of the Pharmacology Department The talk entitled; “Mysterious stellate cell system: A promising targeting designation in myriad pathological conditions.” 2023, Pharos University in Alexandria.
- Attending the workshop entitled; “Creating Interactive Digital Course Content ”, 2023, Pharos University in Alexandria.
- Completion of six workshops from the “Faculty & Leadership Development Center” entitled: Quality Standards in the Educational Process, Examination Systems and Student Evaluation, Preparation of Competitive Research Projects, International Publication of Scientific Research, Flipped Classroom, Use of Global Databases, 2023.
- Attending the workshop entitled; “Environment of online teaching; teaching and learning strategies” Organized by: AUF and the 3rd PUA International Conference, 2022, Pharos University in Alexandria.
- Attending the workshop entitled; “Egyptian Knowledge Bank”, 2022, Pharos University in Alexandria.
- Attending the workshop entitled; “Research metrices”, 2021, Pharos University in Alexandria.
- Attending the workshop entitled; “Crisis Management”, 2021, Pharos University in Alexandria.
- Attending the workshop entitled; “Global Databases”, 2021, Pharos University in Alexandria.
- Participant in the workshop entitled “Research Ethics Capacity Building” Organized by The Egyptian Network for Research Ethics Committees (ENREC), Central Administration for Research and Training at the Ministry of Health, Middle East Research Ethics Training Initiative (MERETI) and the Arab Foundation for the Development of Research Capacity and Ethics (ARECDI), 2020.
- Speaker in the workshop entitled; “Code of Ethics” for academic and administrative staff 2020, Pharos University in Alexandria.
- Attending the workshop entitled; “Competency – based NARS”, 2020, Pharos University in Alexandria.
- Attending the workshop entitled; “Blackboard Features”, 2020, Pharos University in Alexandria
- Attending the workshop entitled; “strategic planning”, 2020, Pharos University in Alexandria
- Attending the workshop entitled; “strategic planning”, 2020, Pharos University in Alexandria
- Attending the workshop entitled; “Innovative problem solving”, 2020, Pharos University in Alexandria
- Attending the workshop entitled; “Advice on Successful Publication”, December 2019, Pharos University in Alexandria
- Speaker in workshops held by UREAC (Talk title: Laboratory Animals Research Ethics) (September 2019)
- Attendee in workshop entitled “Proposal writing for Post Docs” held by DAAD Kairo Akademie in June 2019
- Attending new PhD holders Education Development Center (EDC) five workshops (Syllabus design &Construction, student assessment, interactive modalities, community-based projects, course file & class management), September 2018, Pharos University in Alexandria
- Attending the workshop entitled; “Self-archiving”, 2017, Pharos University in Alexandria.
- Attending the workshop entitled; “International publication & Project funding”, 21.Sept. 2016, Pharos University in Alexandria.
- Attending the workshop entitled; “Scientific writing” July 2015, Pharos University in Alexandria
- . Attending the American Commission on International and Trans-regional Accreditation (CITA) workshops about teaching methodologies in American section -2006, 2007.
- 25. Attendee in the training course “Clinical Practice for Pharmacists (Clinical pharmacology), the medical training department of “ICC” 2005.
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2024
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2023-present
2023
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