PCL09 – Drug synthesis

Course lecturer :

Prof. Dr. Mohamed El Kersh, Prof. Dr. Makarem Saeid and Dr. Mona Abdel Moneim

Course assistant :

Course objectives :

This course deals with the identification of the most suitable methods for synthesis organic and medicinal compounds using the concept of retrosynthetic analysis.

Course description :

• Synthesis of amino acids, peptides and nucleotides.
• Synthesis of some selected drugs including heterocyclic drugs.
• Functional group interconversion and protection of functional groups are illustrated.
• Separation of organic compounds using different chromatographic techniques.
• Retrosynthesis of some drugs.

Course assessment :

Assessment Form Grades ( % )
1. Mid-term exam 40 grades (20 %)
2. Final written exam 80 grades (40 %)
3. Final oral exam 20 marks (10 %)
4. Interactive learning 20 grades (10 %)
5. Course work 40 grades (20%)

Recommended text books :

• Contemporary Drug Synthesis; J. J. Li, D.S. Johnson, D.R. Sliskovic, B.D.Roth John Wiley & Sons., 1st edition, 2004.
• Synthesis of essential drugs; R.S. Vardanyan and V.J. Hruby; Elsveier 2006.
• Recent Advances in Nucleosides: Chemistry and Chemotherapy; C.K. Chu; Elsevier, 1st edition, 2002.
• Christopher A. Langley and Dawn Belcher. Applied pharmaceutical practice (Fasttrach) 2nd edition pharmaceutical press (2012).

Recommended refrences :

• Chemistry& Molecular Aspects Of Drug Design& Action, E.A.Rekka& P.N.Kourouakis, 2008
• Reaction Mechanisms In Organic Synthesis, Rakesh Kumar Parashar, 2009
– Williams R, Aker J, Amidon Get al; The United States Pharmacopeia (2012); United States Pharmacopeial convention, Inc.; 12601 Twin brook Parkway, Rockville, MD 20852.
– The British Pharmacopoeia, (2007), Her Majesty´s Stationery Office, London.