MLHG 201 - Human genetics

Course lecturer :

  • Dr. Nancy Hagras
  • Dr. Bassma Elwakil

Course assistant :

  • N/A

Course objectives :

At the end of the course, the students will be able to; 1- Define the basic concepts of the gene and DNA structure and function. 2- Define and differentiate Mendelian and non-Mendelian modes of inheritance of traits, including quantitative (continuous or multifactorial) traits. 3- Explain the mechanisms of chromosomal structure, DNA replication, transcription, and translation in producing the phenotypic expression of traits, including the mechanisms and effects of DNA mutations and control of gene expression. 4- Describe the chromosomal basis of some genetic disorders and interpret karyotypes. 5- Explain the genetic bases of the immunity in the human immune system and in the development of cancer. 6- Construct and interpret pedigree charts and trace the inheritance of genes in a given family tree. 7- Explain and take stances on issues involving the bioethics of gene sequence usage for screening and profiling of individuals. 8- Describe and explain the main techniques used in DNA cloning, genetic engineering, gene therapy, and biotechnology. 9- Use some online public gene databases to search for and research on specific human genetic disorders.

Course description :

Topics include an introduction to the application of basic genetic principles to the study of human health and disease. An overview of basic human genetics is provided in Mendelian genetics, cytogenetics, population genetics, molecular cytogenetics, oncocytogenetics and clinical applications of principles. The importance and implication of genetic disease at the levels of the population and individual families will be discussed. It also, is designed to cover the basic principles of classical and molecular genetics. Model systems for genetic analysis such as Drosophila melanogaster, Neurospora crassa, and peas will be covered. The course covers a detailed description of the structure and function of nucleic acids. This includes, replication and regulation with emphasis on genetic diseases, mutations, and genetic engineering and its applications will be emphasized.

Course assessment :

Assessment form grades % Mid-Term exam 15 15 Assignment 3 3 Quizzes 4 4 Interactive learning 3 3 Final Written exam 75 75 ———————————————————————- Total 100 100%

Recommended text books :

Genetics Home Reference – Handbook (Help Me Understand Genetics). Lister Hill National Center for Biomedical Communications U.S. National Library of Medicine National Institutes of Health Department of Health & Human Services Published January 27, 2015

Recommended refrences :

Ricki Lewis. Human Genetics, Concepts and Applications. 8th edition. McGraw-Hill Publishers. 2008.